Congratulations to TBBCF 2006 Grantees
(Susan Logan)
The Terri Brodeur Cancer Foundation has awarded three grants of $100,000 each to three researchers. We are blessed with their presence and intense commitment to researching and developing new breast cancer therapies. Their biographies follow below.
Erica Mayer, MD, MPH
Dana-Farber Cancer Institute
Erica writes about herself:
I am originally from suburban Boston, graduated summa cum laude from Williams College, received my medical degree in 2000 from Harvard Medical School, and obtained a Masters in Public Health from the Harvard School of Public Health in 2005. I completed my internal medicine residency at Brigham and Women's Hospital, and my fellowship in Medical Oncology at the Dana-Farber Cancer Institute in Boston. I am currently board certified in Internal Medicine and Medical Oncology. In July 2006, I joined the staff of Dana-Farber as a breast cancer clinician and researcher. I am also an Instructor in Medicine at Harvard Medical School.
My research explores the use of novel agents for the treatment of breast cancer. I design and oversee clinical trials evaluating the role of various antiangiogenic therapies, which target the blood vessels supplying tumors. These treatments appear to have a multitude of effects on the cardiovascular system, and I am currently initiating studies to better understand short and long term consequences of exposure to these agents. Additionally, I am presently leading several efforts at Dana-Farber to introduce new agents into the clinic for the management of triple negative breast cancer, a recently identified aggressive subtype of the disease. [Triple negative breast cancer is usually cancer that is estrogen, progesterone, and Her2Neu gene amplification negative. It associated with more aggressive cancer activity and poorer therapeutic outcomes. Our founder, Norma Logan, was diagnosed with triple negative breast cancer.] In addition to my research work, I maintain a busy clinical practice and serve on the admissions committees for Harvard Medical School and the Brigham and Women's Hospital Internal Medicine Residency Program.
Dr. Samit Chatterjee, PhD
Postdoctoral fellow at Cold Spring Harbor Laboratories
Dr. Chatterjee's young but impressive research career is described below:
Dr. Samit Chatterjee was born in Indore, India. He obtained his Bachelors Degree in Microbiology, Zoology, and Chemistry from Holkar Science College (Indore) in 1993. Having developed a strong interest in biomedical research, he pursued a Masters Degree in Biotechnology at Jawaharlal Nehru University (New Delhi, India) with a fellowship from the Department of Biotechnology, Government of India.
After finishing his Masters program in 1995, he joined a highly competitive Ph.D. program in an internationally recognized premier research institution, the National Centre for Biological Sciences (NCBS), located in the city of Bangalore, southern India. He obtained his Ph.D. from NCBS in 2002 under the mentorship of distinguished cell biologist Dr. Satyajit Mayor. During his Ph.D. research, Dr. Chatterjee carried out novel studies in elucidating the mechanism of cellular retention of folate receptor that is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI)-anchor. The human folate receptor is necessary for uptake of folate, a vitamin involved in DNA synthesis/repair. Folate deficiency has been correlated with higher predisposition to breast cancer, among other types of cancer.
Upon completion of his doctoral work, Dr. Chatterjee initiated his postdoctoral training at Cornell Medical School (New York City, NY) in the laboratory of Dr. Enrique Rodriguez-Boulan, a pioneer in the field of epithelial biology. Here he investigated molecular mechanisms by which epithelial cells establish apical-basal polarity. Normal apical-basal polarity is inherent to all epithelial cells lining ducts in organs such as breast. However, the normal epithelial polarity is lost during initiation and progression of carcinoma.
With a desire to extend his training in cell biology toward understanding the molecular mechanisms of disease, he joined Cold Spring Harbor Laboratory (Cold Spring Harbor, NY) in 2006 as a postdoctoral fellow in the laboratory of Dr. Senthil K. Muthuswamy. At CSHL, Dr. Chatterjee's research goal is to understand how changes in expression of a novel class of molecules that regulate epithelial cell polarity cooperate with oncogenes during metastatic progression in breast cancer. As a long-term career objective, Dr. Chatterjee's seeks to establish his own research laboratory geared toward understanding the mechanism of breast cancer progression.
Dr. Chatterjee was the recipient of fellowships from Council of Scientific and Industrial Research, Graduate Aptitude Test in Engineering, and Department of Biotechnology for higher education in India. He also received a travel award by the American Society for Cell Biology and was selected for the Advanced and Quantitative Light Microscopy Course at Marine Biological Laboratory (Woods Hole, Massachusetts). Dr. Chatterjee takes active interest in promoting the cause of science as evidenced by his membership in scientific bodies such as American Society for Cell Biology, and New York Academy of Sciences.
Andrea Oliver, MD
Surgical Oncologist, Dana Farber Cancer Institute
Dr. Oliver's biography, in her own words, is below:
I had long decided to go to medical school prior to graduating from High School, but was put off by the "pre-med" crowd in college and decided that maturity might be a helpful quality in medicine. So I decided to take time off, work, and be a part of the communities that I had come to love. I worked at Dimmock Community Health Center, then decided to have a closer look at clinical work and moved to Harvard Vanguard Medical Associates Pediatrics Department as a medical assistant and ran a parenting program for pregnant teenagers to improve compliance with pre-post-natal care and coping with parenting responsibilities. The program also pushed to improve teaching around contraception to prevent exposure to STDs and further unwanted pregnancies. The program graduated 10 girls that year, only one of which had a second pregnancy within 2 years, and all except one finished high school and started on junior college or training programs for work in a health care field.
I moved on to do research to help decide whether or not an MD/PhD or an MD degree alone was going to be my initial career path. I had a productive year in Dr. Gail Sonenshein's Lab under Dr. Marcello Arsura's tutelage at Boston University School of Medicine's Department of Biochemistry working on a project looking at signaling pathways in hepatocellular carcinoma, although Dr. Sonenshein's work is primarily in breast cancer. Although strongly encouraged by Dr. Sonenshein to pursue a joint degree at Boston University School of Medicine, I elected to just get an MD as I was getting old and had to get on with my education.
I decided to stay at Boston University for medical school because of the patient population that the main hospital served. Most of the communities I had worked with from college onwards got their care there, and it served members of the community who otherwise could not get access to any medical care. When I applied, and up until my fourth year of medical school, I planned to become a family medicine doctor with plans to undergo an obstetrical fellowship and continue to serve underserved populations either in the US or abroad. Then I went through my surgical rotation. Somehow I got tangled up in surgery and I couldn't get out of it. I loved it. It had this amazingly unique place in patient care that I found intoxicating. Although I loved Boston University and the opportunities it afforded a young surgical resident, I elected to find other pastures for clinical exposure and landed at Brigham and Women's Hospital as a surgical resident.
I had wonderful experiences with the trauma and vascular surgery departments as a medical student, but found that the actual skills and diseases that I found most challenging were those that were related to research that I had done so many years ago. The surgical oncology service had the most technically challenging cases, emotionally and spiritually challenging needs, and the most diverse patient spectrum. Everything that all the other surgical specialties needed technically was necessary in surgical oncology. The frustration in nailing down diagnoses, to taking patients back for further resection (surgery) is professionally challenging. But looking someone in the eye who is crushed under the weight of pain from metastases, explaining diagnoses to distraught families, or holding someone's hand as they pass away can be emotionally devastating. Especially for someone who knows all to well that they too, are human.
Breast Cancer patients had all of the complexity of other oncology patients except that they could go home. It was the one place where there was real hope. One could have real impact and add years to the life of, not just months, one's patients. And in the midst of this realization came the news of my Aunt's cancer diagnosis. I had already planned to go back to the bench to do basic research in surgical oncology, but was not sure what question would be fulfilling enough to keep my attention. Her struggle brought my decision into pinpoint focus. I cannot do anything that I do not believe in. Life is too short to be wasted. Every aspect must be lived to the fullest. Before, I asked other people's questions about their passions. Now I ask my own questions, which have been burned into my life. I would love to say that it is altruistic, but it is not. It is the greedy, selfish need to find the answer. It is the hatred of the idea that another woman or man helplessly suffers because we just don't know how to help them. Or worse, we never tried to find a way.
Like Dr. Iglehart, I believe that we are on the cusp of finding a way to possibly eradicate breast cancer as a source of mortality within the next generation. Much in the same way we saw cervical cancer almost disappear with the introduction of the Pap smear, I believe we too will see a similar paradigm shift in the natural history of breast cancer as a disease. However it takes global thinkers like Dr. Iglehart and others to relentlessly pursue and collaborate for society to reach this challenging goal. I believe the Terri Brodeur Foundation and foundations like it are integral in making research questions translate into treatment answers for patients.
I am a surgeon because I believe the living body is the most magnificent creation on earth. I am a doctor because I cannot stand the toll human suffering takes on the body, whether it be at the hands of war, poverty, or illness. I am a researcher because I believe that science is the most powerful tool of the human mind. I cannot save everyone, I cannot relieve every suffering, I cannot find every answer. But as long as I have the opportunity, I can damn well try. One patient, one day, one question at a time.
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